Nature vs Nurture: The Influence of Environmental Stressors on Cancer Risk and How Your Genes Work
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Recent advances in epigenetics and epigenomics have a tremendous impact on our understanding of biological phenomena and have galvanized the research of complex diseases, notably cancer. Aberrant epigenetic events associated with environmental stressors are essential players in the onset and progression of human malignancies. These influence critical cellular events (such as gene expression, DNA repair, genome stability, and cell death) and promote the emergence of “hallmarks of cancer”. Epigenetic changes may be risk factor-specific (“fingerprints”) that should prove instrumental in discovery of new biomarkers in cancer.
In this lecture, Dr Zdenko Herceg will discuss:
• The state of the science of epigenetics associated with environmental/lifestyle stressors and cancer risk.
• Recent conceptual and technological advances in epigenetics and ongoing efforts aiming to identify epigenetic targets in personalized medicine and molecular epidemiology.