Dr Gothai Sivapragasam

Dr Gothai Sivapragasam

  • Lecturer
Department of Biological Sciences

Biography

Dr Gothai had her primary and secondary school education at Sekolah Kebangsaan Convent Bukit Mertajam. Upon her Malaysian School Certificate (SPM) completion, she was offered a place to pursue her Diploma in Medical Laboratory at a private university, Management & Science University (MSU), at 2007. After that, she pursued her Bachelor degree in Biotechnology at Universiti Malaysia Sabah in 2010 with JPA scholarship, where she gained all the fundamental and applied research knowledge, particularly during her final year project. Her passion in research encouraged her to further her Master degree at University Sains Malaysia (USM) in Molecular Medicine at 2015 under MyBrain15 Scholarship. Her research interest focused on plant extraction and in vitro analysis antibacterial. In 2016, she decided to further her Doctor of Philosophy degree (PhD), to expand her experience and knowledge in the field of Medical Biotechnology particularly in anti-cancer research and graduated at 2019. During her study journey, she was also the recipient of Graduate Research Fellow (GRF) Scheme and MyBrain15 Scholarship to pursue her PhD and was awarded highest cited paper, 2019.After completion, she joined as research advisor position SciGen Sdn Bhd based in India. Her responsibilities were mainly designing research projects and writing scientific articles for publication in academic journals. She then joined Mahsa University as Lecturer  and was engaged academic activities, teaching undergraduate biomedical and also supervising research projects of postgraduate students. 

Academic & Professional Qualifications

  • PhD in Medical Biotechnology (Institute of Biosains, Uinversiti Putra Malaysia)
  • Master in Molecular Medicine (INFORMM, Universiti Sains Malaysia)
  • Bachelor Degree in Biotechnology (Universiti Malaysia Sabah)
  • Diploma in Medical Laboratory Technology (Management & Science University)

Research Interests

  • Cancer Biology
  • Inflammatory Diseases
  • Nanotechnology
  • Natural Products

Notable Publications

1. Oscar, D.H.M., Pooi, L.M., Gothai, S., Antony V.S., Mohammed Safwan, A.K, Aisha, F., Alzahrani, B., Jiabei,T., Thilakavathy, K. Narcisse M.S., Suresh, K.S. (2021). Lipofection of Single Guide RNA Targeting MMP8 Decreases Proliferation and Migration in Lung Adenocarcinoma Cells. Medicina 14:710.

2. Mok, P. L., Anandasayanam, A., Oscar David, H. M., Tong, J., Farhana, A., Khan, M., Gothai, S., Koh, A. E., & Alzahrani, B. (2021). Lung development, repair and cancer: A study on the role of MMP20 gene in adenocarcinoma. PloS one 16(4):e0250552.

3. Gothai S, Muniandy K, Gnanaraj C, Ibrahim IAA, Shahzad N, Al-Ghamdi SS, Ayoub N, Veeraraghavan VP,Kumar SS, Esa NM, Arulselvan P. Pharmacological insights into antioxidants against colorectal cancer: A detailed review of the possible mechanisms. Biomed Pharmacother. 2018; 107:1514-1522.

4. Gothai S, Muniandy K, Kumar SS, Esa NM, Arulselvan P. Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells. Asian Pac J Trop Biomed. 2018; 8: 394-402.

5. Hui, T., Nenyao, Y., Gothai, S., Arulselvan., P., Xinjie, S., Lei, Chen. (2018). Dietary triterpenes in the treatment of type 2 diabetes. Trends Food Sci Technol, 72: 24-44.

6. Muniandy K, Gothai S, Badran KMH, Suresh Kumar S, Esa NM, Arulselvan P. Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway. J Immunol Res. 2018; 20181:3430684.

7. Jaya Seema DM, Saifullah B, Selvanayagam M, Gothai S, Hussein MZ, Subbiah SK, Mohd Esa N, Arulselvan P. Designing of the Anticancer Nanocomposite with Sustained Release Properties by Using Graphene Oxide Nanocarrier with Phenethyl Isothiocyanate as Anticancer Agent. Pharmaceutics. 2018 1;10(3).

8. Muniandy K, Gothai S, Tan WS, Kumar SS, Mohd Esa N, Chandramohan G, Al-Numair KS, Arulselvan P.In Vitro Wound Healing Potential of Stem Extract of Alternanthera sessilis. Evid Based Complement Alternat Med. 2018; 2018 :3142073.

9. Gothai S, Muniandy K, Zarin MA, Sean TW, Kumar SS, Munusamy MA, Fakurazi S, Arulselvan P. Chemical Composition of Moringa oleifera Ethyl Acetate Fraction and Its Biological Activity in Diabetic Human Dermal Fibroblasts. Pharmacogn Mag. 2017;13(3):S462-S469.

10. Barahuie F, Dorniani D, Saifullah B, Gothai S, Hussein MZ, Pandurangan AK, Arulselvan P, Norhaizan ME. Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drugdelivery system. Int J Nanomedicine. 2017 ; 12:2361-2372.

11. Arulselvan P, Tan WS, Gothai S, Muniandy K, Fakurazi S, Esa NM, Alarfaj AA, Kumar SS. AntiInflammatory Potential of Ethyl Acetate Fraction of Moringa oleifera in Downregulating the NF-κB Signaling Pathway in Lipopolysaccharide-Stimulated Macrophages. Molecules. 2016 31; 21(11).

12. Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, Kumar SS. Role of Antioxidants and Natural Products in Inflammation. Oxid Med Cell Longev. 2016; 2016:527-6130.

13. Gothai S, Ganesan P, Park SY, Fakurazi S, Choi DK, Arulselvan P. Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target. Nutrients. 2016 4;8(8).

14. Gothai S, Arulselvan P, Tan WS, Fakurazi S. Wound healing properties of ethyl acetate fraction of Moringa oleifera in normal human dermal fibroblasts. J Intercult Ethnopharmacol.2016;5(1):1-6.

15. Torey A, Vijayarathna S, Jothy SL, Gothai S, Chen Y, Latha LY, Kanwar JR, Dharmaraj S, Sasidharan S. Exploration of the anticandidal mechanism of Cassia spectabilis in debilitating candidiasis. J Tradit Complement Med. 2015 19;6(1):97-104.

16. Vijayarathna S, Gothai S, Jothy SL, Chen Y, Kanwar JR, Sasidharan S. Can Cancer Therapy be Achieved by Bridging Apoptosis and Autophagy: a Method Based on microRNA-Dependent Gene Therapy and Phytochemical Targets. Asian Pac J Cancer Prev. 2015; 16(17):7435-9.

17. Sumathy V, Zakariah Z, Jothy S L, Gothai S, Soudarajan Vijayarathna, Lachimanan Yoga Latha, Yeng Cheng, Sreenivasan Sasidharan. In vitro and in vivo antifungal activity of Cassia surattensis flower against Aspergillus niger. Microbial Pathogenesis. 2014 Dec; 77:7-12.

18. U Seeta Uthaya Kumar , Subramanion L Jothy , Gothai S, Saravanan Dharmaraj , Yeng Chen , Sreenivasan Sasidharan. Standardization and Quality Evaluation of Cassia surattensis seed extract.Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014 Octber; 5:355-363.