Dr Lau Tze Pheng

Dr Lau Tze Pheng

  • Senior Lecturer
  • Programme Leader of BSc (Hons) Biology with Psychology
Department of Biological Sciences

Biography

Dr Lau PhD research focused on the involvement of low-penetrance genes in colorectal cancer, as well as the characterisation of stage-specific gene expression and proteomic profiles of colorectal tumours among the Malaysian cohort. Thereafter, her research expanded into the study of telomere length and telomerase activity, as well as microsatellite instability status of colorectal tumours during her postgraduate research fellowship. She started her early profession as one of the pioneers in setting up a medical testing laboratory focusing on molecular testing in cancers. She have great research interest in molecular oncology, molecular pathology and molecular diagnostics, especially on solid tumour malignancies.

Academic & Professional Qualifications

  • PhD (Molecular Oncology), University of Malaya, Kuala Lumpur, Malaysia (2014)
  • BSc (Hons) Biomedical Science, University of Malaya, Kuala Lumpur, Malaysia (2007)
  • Postdoctoral Research Fellowship, Department of Pathology, Faculty of Medicine, University of Malaya (2014-2016)

Research Interests

  • Cancer genetics on solid tumours
  • Molecular pathology to aid in the diagnosis, prognostication, and treatment response prediction of cancer patients

Notable Publications

  1. TP Lau, LH Lian, SY Tan and KH Chua (2008) VNTR polymorphisms of the IL-1RN gene: IL-1RN*1 allele and the susceptibility of SLE in the Malaysian population. International Journal of Biomedical and Pharmaceutical Sciences 2: 34-37.
  2. TP Lau, LH Lian, SM Puah, CH Chew, SY Tan and KH Chua (2008) Lack of association between CD28 IVS3 +17T/C SNP and the susceptibility to SLE in the Malaysian population. Asia-Pacific Journal of Molecular Biology and Biotechnology 16: 85-88.
  3. KH Chua, TP Lau, NA Rahman, SK Wong and RY Othman (2008) Identification of gold binding peptides using a phage display peptide library. Canadian Journal of Pure and Applied Sciences 2: 497-501.
  4. KH Chua, TP Lau, CT Foo, SY Tan and LH Lian (2008) Genetic polymorphisms of the TNF-α and TNF-β genes in Malaysian SLE patients. International Journal of Biomedical and Pharmaceutical Sciences 2: 28-33.
  5. KH Chua, TP Lau, ZY Tee, SY Tan and LH Lian (2009) Genetic polymorphisms of the interleukin-1 beta (IL-1β) -511 and +3954 single nucleotide polymorphisms (SNPs) in Malaysian systemic lupus erythematosus (SLE) patients. Journal of Health Science 55: 657-662.
  6. LH Lian, TP Lau, AS Ching and KH Chua (2012) Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients. Genetics and Molecular Research 11: 863-871.
  7. LH Lian, TP Lau, VL Lee, WS Lee, I Hilmi, KL Goh and KH Chua (2013) Lack of association between TYK2, STAT3 genes and Crohn's disease in the Malaysian population. Genetics and Molecular Research 12: 167-174.
  8. TP Lau, AC Roslani, LH Lian, PC Lee, I Hilmi, KL Goh and KH Chua (2014) NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer. Genetics and Molecular Research 13: 7079-7085.
  9. TP Lau, AC Roslani, LH Lian, PC Lee, I Hilmi, KL Goh and KH Chua (2014) Association between the EGF, VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population. Genetics and Molecular Research 13: 5555-5561.
  10. TP Lau, AC Roslani, LH Lian, HC Chai, PC Lee, I Hilmi, KL Goh and KH Chua (2014) Pair-wise comparison analysis of differential expression of mRNAs in early and advanced stage primary colorectal adenocarcinomas. BMJ Open 4: e004930, doi: 10.1136/bmjopen-2014-004930.
  11. TP Lau, AC Roslani and KH Chua (2014) Stage-specific proteomic profiles of primary colorectal adenocarcinomas in Malaysian patients. European Journal of Cancer 50 (Suppl. 4): e61.
  12. KH Chua, SC Lim, CC Ng, PC Lee, YAL Lim, TP Lau and HC Chai (2015) Development of high resolution melting analysis for the diagnosis of human malaria. Scientific Reports 5: 15671.
  13. KH Chua, LH Lian, XJ Sim, TE Cheah and TP Lau (2015) Association between PDCD1 gene polymorphisms and risk of systemic lupus erythematosus in three main ethnic groups of the Malaysian population. International Journal of Molecular Sciences 16: 9794-9803.
  14. PL Kong, LM Looi, TP Lau and PL Cheah (2016) Assessment of telomere length in archived formalin-fixed, paraffinized human tissue is confounded by chronological age and storage duration. PLoS One 11: e0161720.
  15. TP Lau, LH Lian, PL Cheah, LM Looi, AC Roslani, KL Goh, PC Lee and KH Chua (2017) Lack of correlation between X-ray repair cross-complementing group 1 gene polymorphisms and the susceptibility to colorectal cancer in a Malaysian cohort. European Journal of Cancer Prevention, doi: 10.1097/CEJ.0000000000000336.
  16. PL Cheah, J Li, LM Looi, CC Koh, TP Lau, SW Chang, KH Teoh, KS Mun and AR Nazarina (2019) Screening for microsatellite instability in colorectal carcinoma: practical utility of immunohistochemistry and PCR with fragment analysis in a diagnostic histopathology setting. The Malaysian Journal of Pathology 41: 91-100.
  17. PL Kong, PL Cheah, KS Mun, SF Chiew, TP Lau, CC Koh, KH Teoh, AR Nazarina and LM Looi (2020) FISHing for 1p19q codel in oligodendroglioma. The Malaysian Journal of Pathology 42: 369-376.