Dr Wu Yuan Seng

Dr Wu Yuan Seng

Dr Wu Yuan Seng

  • Programme Leader of Doctor of Philosophy in Biology
Sunway Microbiome Centre

Biography

Dr Wu graduated with first class and Vice Chancellor Award for his Bachelor’s degree. He then completed his PhD in Cancer Pharmacology and Therapeutics at the Department of Pharmacology, Faculty of Medicine, University of Malaya. He was then completed his short-term research fellow in cancer research at the School of Pharmacy, Monash University Malaysia in collaboration with the School of Bioscience, University of Nottingham Malaysia. He is now joining the Centre for Virus and Vaccine Centre and Department of Biological Sciences, School of Medical and Life Sciences, Sunway University. His research interests lie in searching for potential anticancer and antiviral agents and understanding their associated molecular mechanism(s), as well as developing efficient drug delivery or targeting system to cancer cells or virus-infected cells.

Academic & Professional Qualifications

  • PhD in Pharmacology (Cancer Pharmacology Therapeutics), Univesity of Malaya (2017)
  • BSc (Hons) in Industrial Biotechnology (Medical Microbiology and Cancer Pharmacognosy), Universiti Industri Selangor (2010)
  • Postgraduate Certificate in Pro Genetics - Cancer Genomics and Precision Oncology, Harvard Medical School, USA (2020)
  • Postgraduate Certificate in Pro Pharmacology – Essentials, Havard Medical School, USA (2020)

Research Interests

  • Molecular pharmacology
  • Molecular biochemistry
  • Cancer pharmacology and therapeutics
  • Drug discovery for cancers, viruses, and metabolic diseases
  • Pharmacognosy
  • Nano-targeting and nano-drug delivery

Notable Publications

  1. Habeebat AdekilekunOyewusi, Yuan Seng Wu, Sher Zaman Safif, Roswanira Abdul Wahab, Mohd Hayrie Mohd Hatta, and Kalaivani Batumalaie. Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against α-glucosidase and α-amylase. Journal of Biomolecular Structure and Dynamics. (2022) 2022:1-6 doi. org/10.1080/07391102.2022.2104375 (IF: 5.235)
  2. Bernadette Xin Jie Tune, Maw Shin Sim, Chit Laa Poh, Rhanye Mac Guad, Choy Ker Woon, Iswar Hazarika, Anju Das, Subash C. B. Gopinath, Mariappan Rajan, Mahendran Sekar, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria, Kalaivani Batumalaie, and Yuan Seng Wu*. (2022) Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors. Journal of Oncology. 2022:1-25 doi.org/10.1155/2022/3249766 (IF: 4.375)
  3. Lanbo Liu, Subash C. B. Gopinath, Yuan Seng Wu, and Weichao Zhao. Gold-enhanced current-volt dielectrode junction for biosensing with an aptamer-insulin-like growth factor-1-antibody sandwich pattern. (2022) Materials Express. 12:1-8 doi:10.1166/mex.2022.2153 (IF: 1.650)
  4. Jia Wer Ee, Rhanye Mac Guad, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria, Ker Woon Choy, Appalaraju Velaga and Yuan Seng Wu*. (2022) Deciphering Synsepalum Dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms. Sains Malaysiana. 51(1):199-208 doi.org/10.17576/jsm-2022-5101-16 (IF: 1.009)
  5. Ummi Zulaiqha Hamid, Maw Shin Sim, Rhanye Mac Guad, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Ker Woon Choy, Ismail Muhamad Fareez, Srinivasa Reddy Bonam, Yuan Seng Wu. (2021). Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancer. Current Molecular Medicine doi.org/10.2174/1566524021666210806162848 (IF: 2.222)
  6. Mohd Nasarudin Watroly, Mahendran Sekar, Shivkanya Fuloria, Siew Hua Gan, Srikanth Jeyabalan, Yuan Seng Wu, Vetriselvan Subramaniyan, Kathiresan V Sathasivam, Subban Ravi, Nur Najihah Izzati Mat Rani, Pei Teng Lum, Jaishree Vaijanathappa, Dhanalekshmi Unnikrishnan Meenakshi, Shankar Mani, Neeraj Kumar Fuloria. (2021). Chemistry, Biosynthesis, Physicochemical and Biological Properties of Rubiadin: A Promising Natural Anthraquinone for New Drug Discovery and Development. Drug Design, Development and Therapy. 15:4527-4549 doi.org/10.2147/DDDT.S338548 (IF: 4.162)
  7. Mohammad Halim Bin Jeinie, Rhanye Mac Guad, Marion M Hetherington, Siew Hua Gan, Yin Nwe Aung, Yuan Seng Wu, Constance Sat Lin Liew, Ramlah George, Waidah Sawatan, Norazmir Md Nor, Nang Kam Oo Leik, Mohd Nazri Bin Mohd Daud and Shutie Fazila Guad. (2021). Comparison of Nutritional Knowledge, Attitudes and Practices between Urban and Rural Secondary School Students: A Cross-sectional Study in Sabah, East Malaysia. Foods. 10(9):2037 doi.org/10.3390/foods10092037 (IF: 4.350)
  8. Kah Min Yap, Mahendran Sekar, Yuan Seng Wu, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Lay Jing Seow, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria and Pei Teng Lum. (2021). Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects. Saudi Journal of Biological Sciences. doi.org/10.1016/j.sjbs.2021.07.046 (IF: 4.219)
  9. Shalini Vellasamy, Dharmani Murugan, Razif Abas, Aspalilah Alias, Wu Yuan Seng and Choy Ker Woon. Biological Activities of Paeonol in Cardiovascular Diseases: A Review. (2021). Molecules. 26(16):4976 doi.org/10.3390/molecules26164976 (IF: 4.411)
  10. Nur Sakinah Muhamad Fadzil, Mahendran Sekar, Siew Hua Gan, Srinivasa Reddy Bonam, Yuan Seng Wu, Pei Teng Lum, Jaishree Vaijanathappa and Shivsharan B. Dhadde. (2021). Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin - A Promising Natural Lead for New Drug Discovery and Development. Drug Design, Development and Therapy. 15(1) doi.org/10.2147/DDDT.S299753 (IF: 4.162)
  11. Rhanye Mac Guad, Yuan Seng Wu, Yin Nwe Aung, Shamala Devi Sekaran, André Barretto Bruno Wilke, Wah Yun Low, Shin Sim Maw, Rogie Royce Carandang, Mohammad Saffree Jeffree, Hamed Taherdoost, Caroline Sunggip, Constance Sat Lin Liew, Chandrika Murugaiah, Vetriselvan Subramaniyan, Nornazirah Azizan. (2021). Different Domains of Dengue Research in Malaysia: A Systematic Review and Meta-Analysis of Questionnaire-Based Studies. International Journal of Environmental Research and Public Health. 18(9):4474 doi.org/10.3390/ijerph18094474 (IF: 3.390)
  12. Suaidah Ramli, Maw Shin Sim, Rhanye M. Guad, Subash Gopinath, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj K. Fuloria, Ker Woon Choy, Sohel Rana, Yuan Seng Wu. (2021). Long Non-Coding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions. Journal of Oncology. Online Ahead of Print doi.org/10.1155/2021/5519720 (IF: 4.375)
  13. Shivkanya Fuloria,Vetriselvan Subramaniyan, Rajiv Dahiya, Sunita Dahiya, Kalvatala Sudhakar,Usha Kumari, Kathiresan Sathasivam, Dhanalekshmi Unnikrishnan Meenakshi, Yuan Seng Wu, Mahendran Sekar, Rishabha Malviya, Amit Singh and Neeraj Kumar Fuloria. (2021). Mesenchymal Stem Cell-Derived Extracellular Vesicles: Regenerative Potential and Challenges. Biology. 10(3):172 doi:10.3390/biology10030172 (IF: 5.079)
  14. Shivkanya Fuloria, Vetriselvan Subramaniyan, Sundram Karupiah, Usha Kumari, Kathiresan Sathasivam, Dhanalekshmi Unnikrishnan Meenakshi, Yuan Seng Wu, Mahendran Sekar, Nitin Chitranshi, Rishabha Malviya, Kalvatala Sudhakar, Sakshi Bajaj and Neeraj Kumar Fuloria. (2021). Comprehensive Review of Methodology to Detect Reactive Oxygen Species (ROS) in Mammalian Species and Establish Its Relationship with Antioxidants and Cancer. Antioxidants. 10(1): 128 doi:10.3390/antiox10010128 (IF: 6.312)
  15. Nurul Wahidah Abdul Wahab, Rhanye Mac Guad, Vetriselvan Subramaniyan, Ismail M. Fareez, Ker Woon Choy, Srinivasa Reddy Bonam, Chandrasekaran Selvaraju, Maw Shin Sim, Subash C.B. Gopinath and Yuan Seng Wu. (2021). Human Exfoliated Deciduous Teeth Stem Cells: Features and Therapeutic Effects on Neurogenerative and Hepatobiliary-Pancreatic Diseases. Current Stem Cell Research & Therapy. 16(5):563-576 doi:10.2174/1574888X15999200918105623 (IF: 3.828)
  16. Shikanya Fuloria, Vetriselvan Subramaniyan, Sundram Karupiah, Usha Kumari, Kathiresan Sathasivam, Dhanalekshmi Unnikrishnan Meenakshi, Yuan Seng Wu, Rhanye Mac Guad, Kaviraja Udupa and Neeraj Kumar Fuloria. (2020). A Comprehensive Review on Source, Types, Effects, Nanotechnology, Detection, and Therapeutic Management of Reactive Carbonyl Species Associated with Various Chronic Diseases. Antioxidants. 9(11):1075 doi:10.3390/antiox9111075 (IF: 6.312)
  17. Yu Wang, Yan Guo, Jianguang Lu, Yanan Sun, Xiaoguang Yu, Subash C.B. Gopinath, Thangavel Lakshmipriya, Yuan Seng Wu, Chao Wang. (2020). Nano-detection of Head and Neck Cancer on Titanium Oxide Sensing Surface. Nanoscale Research Letters. 15(33):1-9 doi:10.1186/s11671-020-3262-x (IF: 4.703)
  18. Puvanesswaray Ramakrishnan, Subash CB Gopinath, Srinivasa R Bonam, Ismail M Fareez, Rhanye M Guad, Maw Shin Sim, Yuan Seng Wu. (2020). Selective Phytochemicals Targeting Pancreatic Stellate Cells as New Anti-Fibrotic Agents for Chronic Pancreatitis and Pancreatic Cancer. Acta Pharmaceutica Sinica B doi:10.1016/j.apsb.2019.11.008 (IF: 11.413)
  19. Srinivasa Reddy Bonam, Yuan Seng Wu, Lakshmi Tunki, Ranjithkumar Chellian Mahabalarao Sampath Kumar Halmuthur, Syviane Muller and Vijayapandi Pandy. (2018). What has come out from phytomedicines and herbal edibles for the treatment of cancer? ChemMedChem. 13(18):1854-1872 doi:10.1002/cmdc.201800343 (IF: 3.009)
  20. Yuan Seng Wu, Lay Hong Chuah, Chun Wai Mai, Siew Ching Ngai. (2018). Epigenetics in Metastatic Breast Cancer: Its Regulation and Implications in Diagnosis, Prognosis and Therapeutics. Current Cancer Drug Targets. 19(2):82-100 doi:10.2174/1568009618666180430130248 (IF: 2.626)
  21. Yuan Seng Wu, Siew Cing Ngai, Bey Hing Goh, Kok Gan Chan Learn Han Lee, Lay Hong Chuah. (2017). Anti-cancer Activity of Surfactin and Potential Application of Nanotechnology Assisted Surfactin Delivery. Frontiers in Pharmacology. 761(8):1-22 doi:10.3389/fphar.2017.00761 (IF: 4.400)
  22. Maw Shin Sim, Tomato Saga, Vijayapandi Pandy, Yuan Seng Wu, Ishwar S. Parhar, Zahurin Mohamed. (2017) MicroRNA expression signature of methamphetamine use and addiction in the rat nucleus accumbens. Metabolic Brain Disease. 32(6):1767-1783 doi:10.1007/s11011-017-0061-x (IF: 2.297)
  23. Yuan Seng Wu, Ivy Chung, Won Fen Wong, Atsushi Masamune, Maw Shin Sim, Chung Yeng Looi. (2016). Paracrine IL-6 signaling mediates the effect of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells. BBA- General Subjects. 1861(2):296-306 doi:10.1016/j.bbagen.2016.10.006 (IF: 5.083)
  24. Yuan Seng Wu, Chung Yeng Looi, Kavita S. Subramaniam, Atsushi Masamune, Ivy Chung. (2016). Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification. Oncotarget. 7(24):36719-36732 doi:10.18632/oncotarget.9165 (IF: 5.168)
  25. Unravelling the Anti-dengue Effects of Selected Withanolides of Withania somnifera Using In Vitro Infectivity Assays and In Silico Analysis – RM 40,000 funded by Sunway University (GRTIN-IGR-CVVR[S]-03-2022) [Principal Investigator]
  26. Attiq, A., Afzal, S., Wahab, H. A., Ahmad, W., Kandeel, M., Almofti, Y. A., Alameen, A. O., & Wu, Y. S. (2024). Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches. Drug design, development and therapy, 18, 4215–4240. https://doi.org/10.2147/DDDT.S475005
  27. Muralikrishnan, A., Sekar, M., Kumarasamy, V., Gan, S. H., Ravi, S., Subramaniyan, V., Wong, L. S., Wu, Y. S., Khattulanuar, F. S., & Mat Rani, N. N. I. (2024). Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development. Drug design, development and therapy, 18, 3741–3763. https://doi.org/10.2147/DDDT.S476279
  28. Nair, A. S., Sekar, M., Gan, S. H., Kumarasamy, V., Subramaniyan, V., Wu, Y. S., Mat Rani, N. N. I., Ravi, S., & Wong, L. S. (2024). Lawsone Unleashed: A Comprehensive Review on Chemistry, Biosynthesis, and Therapeutic Potentials. Drug design, development and therapy, 18, 3295–3313. https://doi.org/10.2147/DDDT.S463545
  29. Afzal, S., Attiq, A., Wu, Y. S., Alameen, A. O., Albokhadaim, I., Kandeel, M., Alhojaily S., Almofti, Y. A., Shousha, S. (2024). Evaluation of Various Experimental Models in Antihypertensive Drug Development: Recent Update. International Journal of Pharmacology, 20(8), 1395-1364. https://doi.10.3923/ijp.2024.1350.1364
  30. Liew, C. S. L., Guad, R. M., Taylor-Robinson, A. W., Teck, K. S., Mandrinos, S., Duin, E. V., Marcus, M., Chua, S. W., Ho, H. L., Lo, Z. Z., Gan, S.H., Wu, Y. S., Sumpat, D., Awang, M. A., Rahman, M. S., Azzani, M. (2024). Antibiotic use in a co-infection of respiratory syncytial virus and pathogenic bacteria in children in a resource-limited setting in northeast Peninsular Malaysia. Tropical Biomedicine, 41(3), 1-6 https://doi.org/10.47665/tb.41.3.011
  31. Banerjee, S., Mukherjee, S., Mohsin Kazi, Sen, K. K., Das, A., Hasan, R., Wu, Y. S., Eftekhari, A., Das, S. K., Nur-E-Alam, M., Sarker, M. M. R., & Nur Azlina, M. F. (2024). Anti- COVID-19 drug discovery by flavonoid derivatives: an extensive computational drug design approach. Cellular and molecular biology (Noisy-le-Grand, France), 70(8), 39–49. https://doi.org/10.14715/cmb/2024.70.8.5
  32. Arumugam, M., Gopinath, S.C.B., Anbu, P. et al. (2024). Efficient Copper Adsorption from Wastewater Using Silica Nanoparticles Derived from Incinerated Coconut Shell Ash. BioNanoSci. 14, 2739–2749 (2024). https://doi.org/10.1007/s12668-024-01523-9
  33. Alagasamy, S. V., Fuloria, S., Franklin, F., Raju, C. S., Jagadeesan, D., Sa'ad, M. A., Veerasamy, R., Subramaniyan, V., Wu, Y. S., Karupiah, S., & Fuloria, N. K. (2024). Synthesis and dengue inhibition potential of new uridine derivatives: The DENV inhibitors. Pakistan journal of pharmaceutical sciences, 37(4), 753–759. https:// doi.org/10.36721/PJPS.2024.37.4.REG.753-759.1
  34. Siddiqui, S. A., Srikanth, S. P., Wu, Y. S., Kalita, T., Ambartsumov, T. G., Tseng, W., Kumar, A. P., Ahmad, A., Michalek, J. E. (2024). Different Types of Algae Beneficial for Bone Health in Animals and in Humans – A Review. Algal Research, 82, 103593. https://doi.org/10.1016/j.algal.2024.103593
  35. Michelle Felicia Lee, Tan, S. L., Nafees Ahemad, A., Abdul Hamid, A. A., Nor Hishamuddin, S. A. S., Batumalaie, K., Afzal, S., Wu, Y. S. (2024). Molecular Docking and Dynamics Simulation Reveal Withanolides As Potent Antivirals Against Dengue Virus. South African Journal of Botany, 169, 426-434. https://doi.org/10.1016/j.sajb.2024.04.045
  36. l Quwatli, L., Lee, M.F., Wu, Y.S. et al. Antiviral Activity of Withanolide A Against Different Infectivity Phases of Dengue Virus Serotype 2 in Vero Cell Line. Rev. (2024). Revista Brasileira de Farmacognosia, 34, 609–617. https://doi.org/10.1007/s43450-023-00510-7
  37. Siddiqui, S. A., Baruah S., Wu, Y. S., Yuansah, S. C., Castro-Muñoz R., Szymkowiak A., Kulawik, P. (2024). Sustainable Production and Consumption, 46, 400-417.
  38. Siddiqui, S. A., Harahap, I. A., Osei-Owusu, J., Saikia, T., Wu, Y. S., Fernando, I., Perestrelo, R., Câmara, J. S. (2024). Bioconversion of organic waste by insects – A comprehensive review. Process Safety and Environmental Protection, 187, 1-25. https://doi.org/10.1016/j.psep.2024.04.122
  39. Xin Jie Tune, B., Seng Wu, Y., Mac Guad, R., Syamima Abd Manap, A., Afzal, S., Batumalaie, K., … Sekar, M. (2024). Preclinical Therapeutic Effects of Quercetin on Gastrointestinal Cancers. IntechOpen. doi: 10.5772/intechopen.1004556
  40. Wong, M. M., Aziz, N. A., Ch'ng, E. S., Armon, S., Chook, J. B., Bong, J. J., Peh, S. C., Wu, Y. S., & Teow, S. Y. (2024). Expression of LC3A, LC3B and p62/SQSTM1 autophagy proteins in hepatocellular carcinoma (HCC) tissues and the predicted microRNAs involved in the autophagy-related pathway. Journal of molecular histology, 55(3), 317–328. https://doi.org/10.1007/s10735-024-10191-8
  41. Afzal, S., Wu, Y. S., Zelynn, C., Appalaraju, V. (2024). In vitro cytotoxic activity of Sansevieria trifasciata against various cancer cell lines. Tropical Journal of Pharmaceutical Research. 23(3), 491-499. https://doi.org/10.4314/tjpr.v23i3.2
  42. Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., & Dey, A. (2021). Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 143, 112175. https://doi.org/10.1016/j.biopha.2021.112175
  43. Jain, A., Ravichandran, M., Ugrappa, S., Lalitha, P., Wu, Y. S., Noor, S. N. F. M., Fuloria, S., Subramaniyan, V., Fuloria, N. K. (2024). Synthesis, Characterization and Response of Newer Benzamidine Analogues against Porphyromonasgingivalis mediated Peri-Implantitis. Asian Journal of Chemistry, 36(4), 829-836. https://doi.org/10.14233/ajchem.2024.31103
  44. Hamrayev, H., Jazayeri, S. D., Yusefi, M., Brianna, Teow S. T., Wu, Y. S., Anwar, A., Korpayev, S., Kartouzian, A., Shameli, K. (2024). Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity. Particle & Particle Systems Characterization, 41, 240009 https://doi.org/10.1002/ppsc.202400009
  45. Brianna B., Masnammany A. M., Wu Y. S. (2024). A review on cytomegalovirus in patients with autoimmune inflammatory rheumatic diseases: Prevalence, clinical spectrum, treatment, and antiviral prophylaxis. Proceedings of Singapore Healthcare. 2024;33. https://doi:10.1177/20101058241241914
  46. Siddiqui, S.A., Ngah, N., Wu, Y.S., Kalita, T., Yudhistira, B., & Ibrahim, S.A. (2024). Lab-grown insect meat – Chemical and biological insights – A comprehensive review. Journal of Insects as Food and Feed (published online ahead of print 2024). https://doi.org/10.1163/23524588-00001131
  47. Stephen, A., Tune, B. X. J., Wu, Y. S., Batumalaie, K., Sekar, M., Sarker, M. M. R., Subramaniyan, V., Fuloria, N. K., Fuloria, S., & Gopinath, S. C. B. (2024). Withanone as an Emerging Anticancer Agent and Understanding Its Molecular Mechanisms: Experimental and Computational Evidence. Current cancer drug targets, 10.2174/0115680096290673240223043650. Advance online publication. https://doi.org/10.2174/0115680096290673240223043650
  48. Siddiqui, S.A., Yüksel, A.N., Şahin Ercan, S., Abdul Manap, A.S., Afzal, S., Wu, Y.S., Yudhistira, B., & Ibrahim, S.A. (2024). Edible beetles (Coleoptera) as human food – A comprehensive review. Journal of Insects as Food and Feed (published online ahead of print 2024). https://doi.org/10.1163/23524588-00001095
  49. M. Sofiullah, S. S., Murugan, D. D., Abd Muid, S., Wu, Y. S., Zamakshshari, N. H., Gan, Q. F., Patrick, M., Ab Azis, N., Rao, S. (2024). Sains Malaysiana, 53(3), 591-604. http://doi.org/10.17576/jsm-2024-5303-09
  50. Siddiqui, S.A., Wu, Y.S., Vijeepallam, K., Batumalaie, K., Hatta, M.H.M., Lutuf, H., Castro-Muñoz, R., Fernando, I., & Ibrahim, S.A. (2024). Alphitobius diaperinus larvae (lesser mealworm) as human food – An approval of the European Commission – A critical review. Journal of Insects as Food and Feed (published online ahead of print 2024). https://doi.org/10.1163/23524588-20240133
  51. Yong, P. H., New, S. Y., Azzani, M., Wu, Y. S., Chia, V. V., & Ng, Z. X. (2024). Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review. Endocrine regulations, 58(1), 26–39. https://doi.org/10.2478/enr-2024-0004
  52. Bernadette Tune, X. J., Annatasha Stephen, A., Rhanye Mac Guad, R. M., Fuloria, N. K., Subramaniyan, V., Sekar, M., Wu, Y. S. (2024). Pharmacological Management of Tuberculosis, Challenges, and Potential Strategies. Progress in Drug Discovery & Biomedical Science, 7(1), 1-14 https://doi.org/10.36877/pddbs.a0000438
  53. Siddiqui, S.A., Asante, K., Ngah, N., Saraswati, Y.R., Wu, Y.S., Lahan, M., Aidoo, O.F., Fernando, I., Povetkin, S.N., & Castro-Muñoz, R. (2024). Edible dragonflies and damselflies (order Odonata) as human food – A comprehensive review. Journal of Insects as Food and Feed (published online ahead of print 2024). https://doi.org/10.1163/23524588-20230097
  54. Wu, Y. S., Osman, A. I., Hosny, M., Elgarahy, A. M., Eltaweil, A. S., Rooney, D. W., Chen, Z., Rahim, N. S., Sekar, M., Gopinath, S. C. B., Mat Rani, N. N. I., Batumalaie, K., & Yap, P. S. (2024). The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review. ACS omega, 9(5), 5100–5126. https://doi.org/10.1021/acsomega.3c07047
  55. Anwar, A., Teow, S. Y., Wu, Y. S. (2024). Nanogel-based drug delivery system as a treatment modality for diverse diseases: Are we there yet? Journal of Drug Delivery Science and Technology, 91, 105224 https://doi.org/10.1016/j.jddst.2023.105224

Achievements & Accolades

  1. Elucidation of Therapeutic Effects of Karanjin and Karanjin-loaded Chitosan Nanoparticles against Microglial Cells-Mediated Neuroinflammmation using In vitro and In silico Analyses – RM 6,000 funded by Brain, Mind and Neuroscience Researh Foundation (GRTEX-OTR-CVVR-YPOMNM-001-2022) [Principal Investigator]
  2. Differential Analysis of Intestinal Microbiota and Its Relationship to Different Incidence and Clinicopathological Features of Colorectal Cancer among the Multiethnic Patients in Malaysia – RM 40,000 funded by Sunway University (GRTIN-IGS(02)-DBS-14-2022) [Co-Investigator]
  3. Evaluation of Thiourea Derivatives as Potential Anti-dengue Therapeutics by In Vitro and In Silico Approaches – RM 40,000 funded by Sunway University (GRTIN-IGS(02)-RCCM-08-2022) [Co-Investigator]
  4. Characterization of modulator of apoptosis 1 (MOAP-1) protein in oxidative stress-induced neuronal cell death: therapeutic implications for neurological diseases – RM 20,000 funded by Sunway University (GRTIN-KSGS(02)-DBS-06-2022) [Co-Investigator]
  5. Characterization of modulator of apoptosis 1 (MOAP-1) protein in oxidative stress-induced neuronal cell death: therapeutic implications for neurological diseases – RM 20,000 funded by Sunway University (GRTIN-KSGS(02)-DBS-06-2022) [Co-Investigator]
  6. Unravelling the Anti-dengue Effects of Selected Withanolides of Withania somnifera Using In Vitro Infectivity Assays and In Silico Analysis – RM 7,600 funded by Sunway University Rewarding Research Output (RRO) 2022 (GRTIN-RRO-25-2022) [Principal Investigator]
  7. Unravelling the Anti-dengue Effects of Selected Withanolides of Withania somnifera Using In Vitro Infectivity Assays and In Silico Analysis – RM 40,000 funded by Sunway University (GRTIN-IGR-CVVR[S]-03-2022) [Principal Investigator]
  8. Elucidation of the Effects of Cigarette, Electronic Cigarette and Dual-Use on Cellular Morphology, Biochemical and Genetic Profile Alterations of Smokers – RM 217,610 funded by Fundamental Research Grant Scheme (FRGS/1/2020/SKK05/UM/02/1) [Co-Investigator]
  9. Genome-wide Pharmacogenomics Study on Polydrug Abuse and Dependence, and Therapeutic Response of Methadone Maintenance Treatment at Selected Hot Spots in Malaysia – funded by Long Term Research Grant Scheme 2019-1 [Co-Investigator]
  10. Behavioral of Tetraspanin L6 Domain Family on Esophageal Squamous Cell Carcinoma Phenotypes and Chemoresistance: Investigation on MicroRNAs and Aptamer-Based Treatment – RM 166,000 funded by Fundamental Research Grant Scheme (FRGS/1/2019/SKK10/MAHSA/03/1) [Co-Investigator]
  11. Potential Role of Tetraspanin L6 Domain Family on Chemoresistance of Esophageal Squamous Cell Carcinoma and Application of Aptamer-Based Treatment - RM 33,000 (RP165-05/19) funded by MAHSA University [Principal Investigator]
  12. 2 Dimensional (2D) Geometry Morphometry Analysis of Human Cervical Vertebra from Xray for Identification of Malaysia Population – RM 26,000 (RP164-05/19) funded by MAHSA University [Co-Investigator]

 

Last Three Years

  1. Elucidating Withanolides as an Anti-Stromal Agent in Mitigating Stellate Cells-Mediated Pancreatic Ductal Adenocarcinoma Malignant Phenotypes with Mechanistic Insight on Long Noncoding RNAs Expression – RM 50,000 funded by Majlis Kanser Nasional (MAKNA) [Principal Investigator]
  2. Evaluation of Anti-obesity Activity on the Natural Karanjin Molecule through the Adipogenesis Pathway using a High-Fat Diet-Induced Rat Model – RM 163,810 funded by Fundamental Research Grant Scheme, Ministry of Higher Education Malaysia (FRGS/1/2023/SKK10/MUSM/02/3) [Co-Investigator]
  3. Evaluation of Antiviral Activity and Serum Stability of Selected Antiviral Peptides with Nanoparticle Encapsulation Against Four Dengue Virus Serotypes – RM 40,000 funded by Sunway University (GRTIN-IGS(02)-CVVR-13-2023) [Principal Investigator]
  4. Comparative Analysis of the Immunogenicity of Plasmid DNA and Recombinant Peptide Vaccine Candidates against SARS-CoV-2 – RM 40,000 funded by Sunway University (GRTIN-IGS(02)-CVVR-11-2023) [Principal Investigator]
  5. Elucidation of Therapeutic Effects of Karanjin and Karanjin-loaded Chitosan Nanoparticles against Microglial Cells-Mediated Neuroinflammmation using In vitro and In silico Analyses – RM 6,000 funded by Brain, Mind and Neuroscience Researh Foundation (GRTEX-OTR-CVVR-YPOMNM-001-2022) [Principal Investigator]
  6. Differential Analysis of Intestinal Microbiota and Its Relationship to Different Incidence and Clinicopathological Features of Colorectal Cancer among the Multiethnic Patients in Malaysia – RM 40,000 funded by Sunway University (GRTIN-IGS(02)-DBS-14-2022) [Co-Investigator]
  7. Evaluation of Thiourea Derivatives as Potential Anti-dengue Therapeutics by In Vitro and In Silico Approaches – RM 40,000 funded by Sunway University (GRTIN-IGS(02)-RCCM-08-2022) [Co-Investigator]
  8. Characterization of modulator of apoptosis 1 (MOAP-1) protein in oxidative stress-induced neuronal cell death: therapeutic implications for neurological diseases – RM 20,000 funded by Sunway University (GRTIN-KSGS(02)-DBS-06-2022) [Co-Investigator]
  9. Unravelling the Anti-dengue Effects of Selected Withanolides of Withania somnifera Using In Vitro Infectivity Assays and In Silico Analysis – RM 7,600 funded by Sunway University Rewarding Research Output (RRO) 2022 (GRTIN-RRO-25-2022) [Principal Investigator]
  10. Unravelling the Anti-dengue Effects of Selected Withanolides of Withania somnifera Using In Vitro Infectivity Assays and In Silico Analysis – RM 40,000 funded by Sunway University (GRTIN-IGR-CVVR[S]-03-2022) [Principal Investigator]